Acetonitrile laboratory use

Acetonitrile is a commonly used polar aprotic solvent. In inorganic chemistry, acetonitrile is widely used as a ligand, and its abbreviation is MeCN. For example, acetonitrile complex PdCl2 (MeCN) 2 can be prepared by heating the suspension of polymerized palladium chloride in acetonitrile.

Acetonitrile is a popular solvent for cyclic voltammetry because of its high dielectric constant. Acetonitrile is also a carbon dioxide raw material for organic synthesis. It can react with cyanogen chloride to obtain malononitrile. Acetonitrile is also used as a mobile phase separation molecule and is commonly used in column chromatography and more modern high performance liquid chromatography. In the field of nuclear medicine, acetonitrile is used to synthesize fluorodeoxyglucose and other positron radiopharmaceuticals. In the process of synthesizing FDG, the evaporation of acetonitrile can take away the water in the reaction system; The amount of acetonitrile in the reaction system has a decisive influence on the synthetic efficiency of FDG and the quality of drugs; At the same time, acetonitrile is also used as the solvent and the matrix of the reaction system.

In addition, in the routine quality inspection of FDG, acetonitrile: water mixture (for example, 85%? V/v) is also used as the mobile phase for thin-layer chromatographic analysis.