ACA-PEG-NH2 (acrylamide Polyethylene Glycol Amino)

Aminoated polyethylene glycol derivatives can be used to modify proteins, peptides and other materials and small molecules with carboxyl groups (-cooh) or other active groups that can react with primary amines. Amino groups can easily form stable amide bonds with carboxyl groups, and can also form amide bonds with active esters (-nhs) at ph7-8.5. Polyethylene glycol can increase solubility and stability. Reduce the immunogenicity of peptides and proteins, and it can also inhibit the nonspecific binding of charged molecules on the modified surface.

Polyethylene glycol (PEG) compounds contain polyether units, usually expressed as R 1 - (o-ch 2 -ch 2) n -or 2. They are usually biocompatible, non-toxic and stable in organic and aqueous solutions, so they are widely used in biological applications, as well as nanotechnology and material research. PEG chain modified proteins and compounds encapsulated in PEG liposomes show longer half-life than their non PEGylated counterparts in vivo, which is called peg shielding. Functionalized peg lipids and phospholipids can be used for protein peg conjugation.